Influence of carboxylation on osteocalcin detection by mass spectrometry
نویسندگان
چکیده
منابع مشابه
Gamma-carboxylation regulates osteocalcin function
The only well described function of vitamin K (VK) is to serve as a co-factor for the γ-carboxylation of particular proteins to convert specific glutamic acid (Glu) residues to γ-carboxyglutamic acid (Gla) residues. This process involves two enzymes, γ-glutamyl carboxylase (γ-carboxylase or GGCX) and vitamin K epoxide reductase (VKORC1), which together constitute the vitamin K cycle [1]. Physio...
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Osteocalcin (OCN) is a small noncollagenous protein mainly produced by osteoblasts and is highly represented in bones of most vertebrates. Human OCN contains up to three gamma-carboxyglutamic acid (Gla-OCN) residues at positions 17, 21 and 24 which are thought to increase calcium binding strength, improving mechanical properties of the bone matrix. Recent studies revealed that OCN exerts also i...
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ژورنال
عنوان ژورنال: Rapid Communications in Mass Spectrometry
سال: 2016
ISSN: 0951-4198
DOI: 10.1002/rcm.7692